Drugs That Cause Depression

Drugs That Cause Depression


The cause of your depression might be the last thing you suspect—and that is, some of the medications you’re prescribed.

The thought itself defeats the purpose, but some of the drugs you take might be the reason you have a hard time fighting your wretchedness and the feelings of hopelessness. Some of these drugs have raised concerns, and it’s for this reason that those who suffer from depression are advised to take them with caution to avoid exacerbating their condition.

How These Drugs Cause Depression

Medications linked with depression trigger the condition by altering brain chemicals. Read this bearing in mind that some of the drugs may be the anti-depressants prescribed to you to treat the condition, but before they get to working and dispelling the feelings of depressions, you may find out that they are actually increasing them.

Well, there’s NO need to worry about this, as the heightening feelings of depression are nothing more than the side effects that you may just experience for a short while as part of receiving your relief.

Examples of drugs linked with depression include Accutane (which treats acne), Statins (for lowering cholesterol levels and preventing heart attacks), Opioids (for calming muscles), Contraceptives, and Benzodiazepines (for treating depression) to name a few.

How to tell if the Drug You’re Using is Causing Depression

First try going through the list of side effects on the package to check if depression or mood swings are among them. You can also try asking around in forums or reading through reviews to find out if they’re reported to alter moods in a bad way.

It’s also important that you ask your doctor if the drugs they have prescribed tinker with moods, and if there are alternatives to settle for in case they do. Your doctor should be able to run you through a list of drugs pointing out which ones among them do cause depression or mania.

Drugs that have been linked with Depression

There are reported cases of depression linked with the following list of drugs, and even though the effects are only mild with some of them, it’s still advisable to talk to your doctor in the event that you’re prescribed any of them to find out more about the risk involved.


The drugs in this category reduce inflammation by signaling cells to go slow on fighting infections. Such drugs include Flovent, Prednisone, Azmacort, hydrocortisone and triamcinolone to name a few.


Prescribed every time someone has an organ transplant, these drugs are meant to suppress the activities of the immune system so at to prevent it from for rejecting the transplanted organ.


Common anti-depressants including Monoamine Oxidase Inhibitors (MAOIs), such as Nardil (phenelzine and tranylcypromine (parnate), Seretonin/Norepinephrien Reuptake inhibitors (SNRIs) such as duloxetine, desvenlafaxine, venlafaxine and Levomilnacipran, Selective Serotonin reuptake inhibitors (SSRIs) such as Fluoexetine, Paroxetine, and Escitalopram, and lastly Tricyclic antidepressant drugs such as Pamelor are all linked with depression.

Other Drugs linked with depression

  • Carbidopa or Levodopa Drugs, including Duopa, Sinemet and parcopa: These drugs are prescribed for those with Parkinson’s disease.
  • Baclofen Intrathecal or Lioresal: These drugs act as antispatic agents and muscle relaxants. They are often prescribed to those with spinal cord injuries and multiple sclerosis.
  • Antibiotic Drugs such as gentamicin and ciproflazacin
  • Antimalaria drugs like mefloquine and chloronquine

The listed drugs could potentially cause depression. The point is NOT to avoid them, but to take them with caution, and having talked to your doctor first about your condition.